yi、zhongshushenjingteyixingdanbais100βdetexing
s100βdanbaishis100jiazuzhongzhuyaode、zuijuhuoxingdechengyuan。gaileidanbaishuyusuanxinggaijiehedanbai,youmooredengshoucicongniunaozhongfenlihuode。yinqizaizhongxingphtiaojianxianengrongyu100%baoheliusuananrongye,gumingmingweis100danbai(moore, 1965)。
s100βdanbaiyou2geβyajizucheng。2geβyajitongguobanguangansuancanjixingchengerliujian,yierjutihuoxingxingshicunzaiyushenjingyuanzhong。s100βdanbaitongguopangfenmihezifenmidaodabaowaizuoyongyushenjingyuanheshenjingjiaozhixibao,canyuca2+xinhaozhuandao,qishengwubanshuaiqiwei2 h,zaitineidaixiehoujingshenzangpaichu(wanglizhenheguguixiong,2008)。
cba下注平台 s100βdanbaizaipeitaiqidi14 djiuyouweiruobiaoda,suihouyushenjingxitongshengzhangfayuchengpingxingzengjiadeguanxi,chengnianhouxiangduiwending。zhengchangchengrenxueqingzhonghanliangxiaoyu0.18 ng/ml。shenglinongdudes100βdanbaishiyizhongshenjingyingyangyinzi,juyoucuyousifenliezuoyong,kediaojieshenjingjiaozhixibaodeshengzhang、zengzhi、fenhua,weichigaiwentai,cujinnaodefayu,bingzaixuexijiyizhongfahuiyidingzuoyong。dangshenjingjiaozhixibaobiaodas100βdanbaiguoliangshi,zehuichanshengshenjingduxing,jiasushenjingxitongyanzhengdeehua,bingdaozhishenjingxitonggongnengwenluan(wanglizhenheguguixiong,2008)。
cba下注平台 tu1 xingxingjiaozhixibaoyushenjing、naobuxueguandeguanxi。capillary,maoxixueguan;astrocyte,xingxingjiaozhixibao;axon,zhoutu;myelin,suiqiao;oligodendrocyt,shaotujiaozhixibao;myelinated axon,yousuiqiaodezhoutu。
yue96%des100βdanbaicunzaiyunaonei,zhuyaodingweiyuzhongshushenjingxitongdexingxingxibao、shaotushenjingjiaozhixibaojizhouweishenjingxitongdexuewangxibao,shishenjingxitongdeteyixingdanbai。dangnaobuchuxiansunshangshi,ruquexuequeyanghuowaishangdaozhifuhans100βdanbaidexingxingjiaozhixibaohuaisi、diaowanghuozhefenmizengjia,daliangs100βdanbaishifangjinrunaobucbaxiazhupingtaiyezhong: yibufentongguopohuaidehuotongtouxingzengjiadexue-naopingzhangjinruxueyexunhuan,lingyibufenzetongguonao-naojiyepingzhangjinrunaojiyesuihoujingzhuwangmodoujinruxueyexunhuan,haiyouyibufenjingnao-naojiyepingzhang、xue-naojiyepingzhangjinruxueyexunhuan。xueyezhongdes100βdanbaishuipingzainaosunshanghouyouyidingdeshijianbianhuaguilv,erqieyunaosunshangchengdujiyuhoujinmixiangguan,wendingxingyoubiqitashenjingshenghuazhibiaogao,yincikeyizuoweinaosunshangdeteyixingbiaozhiwu。
cba下注平台 er、zhongshushenjingteyixingdanbais100βdelinchuangyingyong
2.1 s100βzaijingshenfenlie、qingganzhangaidengjingshenjibingzhongdeyingyong
s100βkeyizaijixingjingshenbingfabingshibeijiancechu,shidaibiaoshenjingxibaowanzhengxingdeshenghuabiaoji,yiners100βyuelaiyuebeizhongshi。
2.1.1 jingshenfenliezheng
jingshenfenliezhengshiyijibengexinggaibian,siwei、qinggan、xingweidefenlie,jingshenhuodongyuhuanjingdebuxiediaoweizhuyaotezhengdeyileizuichangjiandejingshenbing。
rothermundtdeng(2001b)dui26lichuyujingshenfenliezhengjixingqideweiyongyaodebingrenjinxingyanjiu,jieguofaxianzaiweiqi6zhoudezhiliaoqianhuanzhexuejiangzhongs100βdeshuipingxianzhugaoyuzhengchangduizhaozu,zhiliaohouhuanzhexuejiangzhongs100βdeshuipingjiejinzhengchangduizhaozu。zaiduipianzhixingjingshenfenliezhenghuanzheyanjiuzhongfaxian,huanzhexuejiangzhongs100βyegaoyuzhengchangduizhaozu(steiner et al, 2006;lara et al, 2001)。
lingwai,rothermundtdeng(2001b)zaiyanjiuzhonghaifaxianjingguo6zhouzhiliaohoujixingjingshenfenliezhenghuanzhedes100βdanbainongduyupanssyinxingyinzifenchengxianzhuzhengxiangguan。erguoneiyanjiuzhe(jijiawudeng,2001)zaiyanjiuzhongyefaxianshoufahuanzhejingguo12zhouzhiliaohouyijimanxingjibinghuanzhedes100βdanbainongduyupanssyinxingyinzifenchengxianzhuzhengxiangguan。zheibiaomings100βdanbainongduyujingshenfenliezhengyinxingzhengzhuangguanxigengweimiqie。
cba下注平台 2.1.2 qingganxingjingshenzhangai
qingganxingjingshenzhangaishiyimingxianerchijiudexinjinggaozhanghuodiluoweizhudeyizujingshenzhangai,bingyouxiangyingdesiweihexingweigaibian,baokuozaokuangzheng、yiyuzheng(handancifazuohefanfufazuo)、shuangxiangqingganzhangai(hanzaokuangxiang、yiyuxianghehunhexiang)jiqitaqingganzhangai,kebanyoujingshenbingxingzhengzhuang,ruhuanjue、wangxiang。daduoshuhuanzheyoufanfufazuodeqingxiang,meicifazuoduokehuanjie,bufenkeyoucanliuzhengzhuanghuozhuanweimanxing。
schreoeterdeng(2002)yongmianyifaguangfajiance20liqingganzhangaizhehuanzheji12lijiankangrenxues100βshuipingshifaxian,yiyuzhenghuanzhes100βdanbaishuipingzhongweishuyuzhengchangduizhaozubijiao,chayijuyoutongjixueyiyi。yongkangyiyuyaowuzhiliaohou,s100βdanbaijiangdichengduyuyiyuzhengyanzhongchengduyouguan。yincis100βdanbaibianhuakenengyuxingxingjiaozhixibaogaibianyouguan,tongguokangyiyuzhiliaoyoukenengshiqihuifu。rothermundtdeng(2001a)cedingle28lihuanyouyiyuzhengdehuanzhexuejiangzhongs100βdeshuiping,jieguoxianshiqis100βshuipingxianzhugaoyuzhengchangduizhaozu。yincis100βdanbaizaitishiqingganzhangaihuanzhedenaosunshangfangmianjuyoujiazhi。
congjingshenfenliezhenghuoyiyuzhengdes100βjiancezhifanwei(xueqingyue0.120 ng/ml,naojiyeyue0.700 ng/ml)laikan,bingweiyoudaliangdeshenjingjiaozhihuoshenjingyuanshoudaopohuai,dankeyirenweijingshenfenliezhengdebingchengzhongcunzaizhejinxingxingdeshenjingbianxing。s100βzengjiakeyifanyingchutuibianjizhi,danzhengmings100βnongdudebianhuabanfanaobingligaibian,xuyaozaijiances100βdexueqinghenaojiyezhongnongdudejichushangjieheyingxiangjishuyijishenjingxinlixueceshidengfangmiandeyanjiu。
cba下注平台 2.2 zhongshushenjingteyixingdanbais100βzaidianxianxingchengzhongdeyingyong
cba下注平台 dianxianshimanxingfanfufazuoxingdeduanzannaogongnengshidiaozonghezheng,yinaoshenjingyuanyichangfangdianyinqifanfuxianxingfazuoweitezheng。dianxianshishenjingxitongchangjianjibingzhiyi,huanbinglvjinciyunaozuzhong。
cba下注平台 sendrowskideng(2004)fenbiecedinghuanyounaojishuihedianxianhuanerxuejiangzhongs100βdeshuipingfaxianliangzhedoucunzainongduzenggaodeqingkuang。ershiyongbiantaotijifamoxing,tongguobijiaos100βjiyinqiaochushuheyeshengxingshudechabie,diaochazaidianxianxingchengguochengzhongdezuoyong。jifahougenjuhaimatihebiantaotijiaozhixibaozhongsuanxingdanbaidebiaodapupingguxingxingjiaozhixibaodehuoxing,jieguoxianshiyeshengxinghejiyinqiaochushuxiangsi,erqieyeshengxingheqiaochushubingmeiyouxianzhubutongdehoufangdianyu。raner,qiaochushunengjifagengxunsu、zhengzhuanggengyanzhongdedianxian。zheixiejieguobiaomingzhengchangshuipingdes100βyouduikangdianxianxingchengdezuoyong(dyck et al, 2002)。yinci,tuiduans100βdanbaiquefadaozhixingxingjiaozhixibaozhongca2+chulinenglijiangdi,kenengshidianxianchanshengdeyuanyin。
cba下注平台 2.3 zhongshushenjingteyixingdanbais100βzaishenjingtuixingxingjibingzhongdeyingyong
shenjingtuixingxingjibingshiyoushenjingyuanhuoqisuiqiaodesangshisuozhi。danaohejisuiyoushenjingyuanzucheng,shenjingyuanyoubutongdegongneng,rukongzhiyundong,chuliganjuexinxi,bingzuochujuece。danaohejisuidexibaoyibanshibuhuizaishengde,suoyiguodudesunhaikenengshihuimiexingde,bukenizhuande,bingsuizheshijiandetuiyierehua,yidaozhigongnengzhangai。
cba下注平台 2.3.1 aercihaimobing(ad)
cba下注平台 aerzihaimobingshiyizhongchixuxinggaojishenjinggongnenghuodongzhangai,jiandanjieshijiushizaimeiyouyishizhangaidezhuangtaixia,jiyi、siwei、fenxipanduan、shikongjianbianren、qingxudengfangmianfashenglezhangai。
duiadhuanzhedeshijianyanjiuxianshi,adhuanzhenaocbaxiazhupingtaizhongsuohandes100β mrnahedanbaizhishuipingjunshenggao,bingfaxianadhuanzhewaizhouxuezhongmianyixibaodes100βbiaodazenggao。zaichengnianrennaonei,s100βzaishenjingkesuxingfangmianqizhongyaozuoyong,ers100βguodubiaoda,kedaozhixibaogujiashiwen、zengsheng,shutuhezhoututuibian,tuchushumujianshao,banyouxingweiyichang,biaoxianchuchidaidegezhongzhengzhuang。yanjiubiaomingadhuanzheyekeyounaogengsibingzao、baizhishusonghexueguanxingweixianyinsu。naoxueliudegaibiankeyinqidianfenyangdanbaideguodubiaoda,cijixingxingjiaozhihuohuahezengzhi,gutuices100βkenengzaiaddefasheng、fazhanjizhizhongyebanyanlezhongyaojiaose(guoyongmeideng,2005)。lingwai,xiaojiaozhixibaoguodubiaodail-1、xingxingjiaozhixibaoguodubiaodas100βyijit2+shenjingyuanxianweichanjiejieduandejinyibulianxiyibeizhengshi(donato et al, 2009)。xiangduijiankangduizhaohewanqiadhuanzhe,zaoqidaozhongqiadhuanzhes100βnaojiyenongdushenggao。wanqihuanzhehezhengchangrenwuchayishenzhigengdi。(lambert et al, 2007)。
2.3.2 keyabing
cba下注平台 keyabingshiyizhonghanjiandezhuyaofashengzai50-70suidekechuanbodenaobing。shouganranderenkeyiyoushuimianwenluan、gexinggaibian、gongjishidiao、shiyuzheng、shijuesangshi、jirouweisuo、jizhenluan、jinxingxingchidaidengzhengzhuang,bingqieduohuizaifabingdeyinianneisiwang。
keyabingshizhongshushenjingbianxingjibingzhongjinzhanzuikuaideyizhong,qijiaozhixibaozengshengyeshizuimingxiande。s100βdanbaizhuyaoyoujiaozhixibaofenmi,keyabinghuanzhenaojiyezhongs100βdanbaihanliangshenggao(kovacs et al, 2004),mingxiangaoyufeichidaizuheqitachidaizuhuanzhe(linshihedeng,2007)。
2.3.3 jiweisuoxingcesuoyinghuazheng
jiweisuoxingcesuoyinghuazhengshiyizhongyundongshenjingyuanjibing,duoyu30-50suifabing,yishangzhizhouweixingtanhuan,xiazhizhongshuxingtanhuan,shangxiayundongshenjingyuanhunhexing、duichengxingsunhaiweitedian,biaoxianweishouleibuweijirouweisuo。
mighelideng(1999)baodaolejiweisuoxingcesuoyinghuazhenghuanzhedejisuishenjingjiaozhixibaoheyundongshenjingyuanzhongdes100βdanbaibiaodashangdiao。danshinaojiyezhongs100βnongduhuisuibingchengzengjiaerjiangdi,jifabingyuechidehuanzhedes100βdanbaishuipingyuedi(sussmuth et al, 2003)。
san、zhongshushenjingteyixingdanbais100βzaijingshenbingkedeyingyong
jingshenleijibinghuanzhedezhongshushenjingxitongdaixiewangwangcunzaizhangai,bufenshenjingxitongkenengcunzaisunshang。duiyujixingjingshenbingren,ketongguojiances100βdanbaidenongdu,dazhipanduanzhongshushenjingxitongsunshangdechengdu。danshi,gaizhibiaojinjinzuoweifuzhuzhenduanzhibiao。quezhenrengxuyikaojinyibudeyingxiangxuehexiangxideshenjinggongnengjiancha。
明德生物中枢神经特异性蛋白S100-β蛋白(S100-β)检测试剂盒是应用免疫层析技术,通过免疫定量分析仪判读,建立的快速、特异、简便的定量检测试剂盒,主要用于脑损伤的辅助诊断、监测病情变化、评估预后。不适用中枢神经系统肿瘤的治疗监测。