yi、zhongshushenjingteyixingdanbais100βdetexing
s100βdanbaishis100jiazuzhongzhuyaode、zuijuhuoxingdechengyuan。gaileidanbaishuyusuanxinggaijiehedanbai，youmooredengshoucicongniunaozhongfenlihuode。yinqizaizhongxingphtiaojianxianengrongyu100%baoheliusuananrongye，gumingmingweis100danbai(moore, 1965)。
s100βdanbaiyou2geβyajizucheng。2geβyajitongguobanguangansuancanjixingchengerliujian，yierjutihuoxingxingshicunzaiyushenjingyuanzhong。s100βdanbaitongguopangfenmihezifenmidaodabaowaizuoyongyushenjingyuanheshenjingjiaozhixibao，canyuca2+xinhaozhuandao，qishengwubanshuaiqiwei2 h，zaitineidaixiehoujingshenzangpaichu(wanglizhenheguguixiong，2008)。
cba下注平台 s100βdanbaizaipeitaiqidi14 djiuyouweiruobiaoda，suihouyushenjingxitongshengzhangfayuchengpingxingzengjiadeguanxi，chengnianhouxiangduiwending。zhengchangchengrenxueqingzhonghanliangxiaoyu0.18 ng/ml。shenglinongdudes100βdanbaishiyizhongshenjingyingyangyinzi，juyoucuyousifenliezuoyong，kediaojieshenjingjiaozhixibaodeshengzhang、zengzhi、fenhua，weichigaiwentai，cujinnaodefayu，bingzaixuexijiyizhongfahuiyidingzuoyong。dangshenjingjiaozhixibaobiaodas100βdanbaiguoliangshi，zehuichanshengshenjingduxing，jiasushenjingxitongyanzhengdeehua，bingdaozhishenjingxitonggongnengwenluan(wanglizhenheguguixiong，2008)。
cba下注平台 tu1 xingxingjiaozhixibaoyushenjing、naobuxueguandeguanxi。capillary，maoxixueguan;astrocyte，xingxingjiaozhixibao;axon，zhoutu;myelin，suiqiao;oligodendrocyt，shaotujiaozhixibao;myelinated axon，yousuiqiaodezhoutu。
yue96%des100βdanbaicunzaiyunaonei，zhuyaodingweiyuzhongshushenjingxitongdexingxingxibao、shaotushenjingjiaozhixibaojizhouweishenjingxitongdexuewangxibao，shishenjingxitongdeteyixingdanbai。dangnaobuchuxiansunshangshi，ruquexuequeyanghuowaishangdaozhifuhans100βdanbaidexingxingjiaozhixibaohuaisi、diaowanghuozhefenmizengjia，daliangs100βdanbaishifangjinrunaobucbaxiazhupingtaiyezhong: yibufentongguopohuaidehuotongtouxingzengjiadexue-naopingzhangjinruxueyexunhuan，lingyibufenzetongguonao-naojiyepingzhangjinrunaojiyesuihoujingzhuwangmodoujinruxueyexunhuan，haiyouyibufenjingnao-naojiyepingzhang、xue-naojiyepingzhangjinruxueyexunhuan。xueyezhongdes100βdanbaishuipingzainaosunshanghouyouyidingdeshijianbianhuaguilv，erqieyunaosunshangchengdujiyuhoujinmixiangguan，wendingxingyoubiqitashenjingshenghuazhibiaogao，yincikeyizuoweinaosunshangdeteyixingbiaozhiwu。
cba下注平台 er、zhongshushenjingteyixingdanbais100βdelinchuangyingyong
2.1 s100βzaijingshenfenlie、qingganzhangaidengjingshenjibingzhongdeyingyong
s100βkeyizaijixingjingshenbingfabingshibeijiancechu，shidaibiaoshenjingxibaowanzhengxingdeshenghuabiaoji，yiners100βyuelaiyuebeizhongshi。
2.1.1 jingshenfenliezheng
jingshenfenliezhengshiyijibengexinggaibian，siwei、qinggan、xingweidefenlie，jingshenhuodongyuhuanjingdebuxiediaoweizhuyaotezhengdeyileizuichangjiandejingshenbing。
rothermundtdeng(2001b)dui26lichuyujingshenfenliezhengjixingqideweiyongyaodebingrenjinxingyanjiu，jieguofaxianzaiweiqi6zhoudezhiliaoqianhuanzhexuejiangzhongs100βdeshuipingxianzhugaoyuzhengchangduizhaozu，zhiliaohouhuanzhexuejiangzhongs100βdeshuipingjiejinzhengchangduizhaozu。zaiduipianzhixingjingshenfenliezhenghuanzheyanjiuzhongfaxian，huanzhexuejiangzhongs100βyegaoyuzhengchangduizhaozu(steiner et al, 2006;lara et al, 2001)。
lingwai，rothermundtdeng(2001b)zaiyanjiuzhonghaifaxianjingguo6zhouzhiliaohoujixingjingshenfenliezhenghuanzhedes100βdanbainongduyupanssyinxingyinzifenchengxianzhuzhengxiangguan。erguoneiyanjiuzhe(jijiawudeng，2001)zaiyanjiuzhongyefaxianshoufahuanzhejingguo12zhouzhiliaohouyijimanxingjibinghuanzhedes100βdanbainongduyupanssyinxingyinzifenchengxianzhuzhengxiangguan。zheibiaomings100βdanbainongduyujingshenfenliezhengyinxingzhengzhuangguanxigengweimiqie。
cba下注平台 2.1.2 qingganxingjingshenzhangai
qingganxingjingshenzhangaishiyimingxianerchijiudexinjinggaozhanghuodiluoweizhudeyizujingshenzhangai，bingyouxiangyingdesiweihexingweigaibian，baokuozaokuangzheng、yiyuzheng(handancifazuohefanfufazuo)、shuangxiangqingganzhangai(hanzaokuangxiang、yiyuxianghehunhexiang)jiqitaqingganzhangai，kebanyoujingshenbingxingzhengzhuang，ruhuanjue、wangxiang。daduoshuhuanzheyoufanfufazuodeqingxiang，meicifazuoduokehuanjie，bufenkeyoucanliuzhengzhuanghuozhuanweimanxing。
schreoeterdeng(2002)yongmianyifaguangfajiance20liqingganzhangaizhehuanzheji12lijiankangrenxues100βshuipingshifaxian，yiyuzhenghuanzhes100βdanbaishuipingzhongweishuyuzhengchangduizhaozubijiao，chayijuyoutongjixueyiyi。yongkangyiyuyaowuzhiliaohou，s100βdanbaijiangdichengduyuyiyuzhengyanzhongchengduyouguan。yincis100βdanbaibianhuakenengyuxingxingjiaozhixibaogaibianyouguan，tongguokangyiyuzhiliaoyoukenengshiqihuifu。rothermundtdeng(2001a)cedingle28lihuanyouyiyuzhengdehuanzhexuejiangzhongs100βdeshuiping，jieguoxianshiqis100βshuipingxianzhugaoyuzhengchangduizhaozu。yincis100βdanbaizaitishiqingganzhangaihuanzhedenaosunshangfangmianjuyoujiazhi。
congjingshenfenliezhenghuoyiyuzhengdes100βjiancezhifanwei(xueqingyue0.120 ng/ml，naojiyeyue0.700 ng/ml)laikan，bingweiyoudaliangdeshenjingjiaozhihuoshenjingyuanshoudaopohuai，dankeyirenweijingshenfenliezhengdebingchengzhongcunzaizhejinxingxingdeshenjingbianxing。s100βzengjiakeyifanyingchutuibianjizhi，danzhengmings100βnongdudebianhuabanfanaobingligaibian，xuyaozaijiances100βdexueqinghenaojiyezhongnongdudejichushangjieheyingxiangjishuyijishenjingxinlixueceshidengfangmiandeyanjiu。
cba下注平台 2.2 zhongshushenjingteyixingdanbais100βzaidianxianxingchengzhongdeyingyong
cba下注平台 dianxianshimanxingfanfufazuoxingdeduanzannaogongnengshidiaozonghezheng，yinaoshenjingyuanyichangfangdianyinqifanfuxianxingfazuoweitezheng。dianxianshishenjingxitongchangjianjibingzhiyi，huanbinglvjinciyunaozuzhong。
cba下注平台 sendrowskideng(2004)fenbiecedinghuanyounaojishuihedianxianhuanerxuejiangzhongs100βdeshuipingfaxianliangzhedoucunzainongduzenggaodeqingkuang。ershiyongbiantaotijifamoxing，tongguobijiaos100βjiyinqiaochushuheyeshengxingshudechabie，diaochazaidianxianxingchengguochengzhongdezuoyong。jifahougenjuhaimatihebiantaotijiaozhixibaozhongsuanxingdanbaidebiaodapupingguxingxingjiaozhixibaodehuoxing，jieguoxianshiyeshengxinghejiyinqiaochushuxiangsi，erqieyeshengxingheqiaochushubingmeiyouxianzhubutongdehoufangdianyu。raner，qiaochushunengjifagengxunsu、zhengzhuanggengyanzhongdedianxian。zheixiejieguobiaomingzhengchangshuipingdes100βyouduikangdianxianxingchengdezuoyong(dyck et al, 2002)。yinci，tuiduans100βdanbaiquefadaozhixingxingjiaozhixibaozhongca2+chulinenglijiangdi，kenengshidianxianchanshengdeyuanyin。
cba下注平台 2.3 zhongshushenjingteyixingdanbais100βzaishenjingtuixingxingjibingzhongdeyingyong
shenjingtuixingxingjibingshiyoushenjingyuanhuoqisuiqiaodesangshisuozhi。danaohejisuiyoushenjingyuanzucheng，shenjingyuanyoubutongdegongneng，rukongzhiyundong，chuliganjuexinxi，bingzuochujuece。danaohejisuidexibaoyibanshibuhuizaishengde，suoyiguodudesunhaikenengshihuimiexingde，bukenizhuande，bingsuizheshijiandetuiyierehua，yidaozhigongnengzhangai。
cba下注平台 2.3.1 aercihaimobing(ad)
cba下注平台 aerzihaimobingshiyizhongchixuxinggaojishenjinggongnenghuodongzhangai，jiandanjieshijiushizaimeiyouyishizhangaidezhuangtaixia，jiyi、siwei、fenxipanduan、shikongjianbianren、qingxudengfangmianfashenglezhangai。
duiadhuanzhedeshijianyanjiuxianshi，adhuanzhenaocbaxiazhupingtaizhongsuohandes100β mrnahedanbaizhishuipingjunshenggao，bingfaxianadhuanzhewaizhouxuezhongmianyixibaodes100βbiaodazenggao。zaichengnianrennaonei，s100βzaishenjingkesuxingfangmianqizhongyaozuoyong，ers100βguodubiaoda，kedaozhixibaogujiashiwen、zengsheng，shutuhezhoututuibian，tuchushumujianshao，banyouxingweiyichang，biaoxianchuchidaidegezhongzhengzhuang。yanjiubiaomingadhuanzheyekeyounaogengsibingzao、baizhishusonghexueguanxingweixianyinsu。naoxueliudegaibiankeyinqidianfenyangdanbaideguodubiaoda，cijixingxingjiaozhihuohuahezengzhi，gutuices100βkenengzaiaddefasheng、fazhanjizhizhongyebanyanlezhongyaojiaose(guoyongmeideng，2005)。lingwai，xiaojiaozhixibaoguodubiaodail-1、xingxingjiaozhixibaoguodubiaodas100βyijit2+shenjingyuanxianweichanjiejieduandejinyibulianxiyibeizhengshi(donato et al, 2009)。xiangduijiankangduizhaohewanqiadhuanzhe，zaoqidaozhongqiadhuanzhes100βnaojiyenongdushenggao。wanqihuanzhehezhengchangrenwuchayishenzhigengdi。(lambert et al, 2007)。
2.3.2 keyabing
cba下注平台 keyabingshiyizhonghanjiandezhuyaofashengzai50-70suidekechuanbodenaobing。shouganranderenkeyiyoushuimianwenluan、gexinggaibian、gongjishidiao、shiyuzheng、shijuesangshi、jirouweisuo、jizhenluan、jinxingxingchidaidengzhengzhuang，bingqieduohuizaifabingdeyinianneisiwang。
keyabingshizhongshushenjingbianxingjibingzhongjinzhanzuikuaideyizhong，qijiaozhixibaozengshengyeshizuimingxiande。s100βdanbaizhuyaoyoujiaozhixibaofenmi，keyabinghuanzhenaojiyezhongs100βdanbaihanliangshenggao(kovacs et al, 2004)，mingxiangaoyufeichidaizuheqitachidaizuhuanzhe(linshihedeng，2007)。
2.3.3 jiweisuoxingcesuoyinghuazheng
jiweisuoxingcesuoyinghuazhengshiyizhongyundongshenjingyuanjibing，duoyu30-50suifabing，yishangzhizhouweixingtanhuan，xiazhizhongshuxingtanhuan，shangxiayundongshenjingyuanhunhexing、duichengxingsunhaiweitedian，biaoxianweishouleibuweijirouweisuo。
mighelideng(1999)baodaolejiweisuoxingcesuoyinghuazhenghuanzhedejisuishenjingjiaozhixibaoheyundongshenjingyuanzhongdes100βdanbaibiaodashangdiao。danshinaojiyezhongs100βnongduhuisuibingchengzengjiaerjiangdi，jifabingyuechidehuanzhedes100βdanbaishuipingyuedi(sussmuth et al, 2003)。
san、zhongshushenjingteyixingdanbais100βzaijingshenbingkedeyingyong
jingshenleijibinghuanzhedezhongshushenjingxitongdaixiewangwangcunzaizhangai，bufenshenjingxitongkenengcunzaisunshang。duiyujixingjingshenbingren，ketongguojiances100βdanbaidenongdu，dazhipanduanzhongshushenjingxitongsunshangdechengdu。danshi，gaizhibiaojinjinzuoweifuzhuzhenduanzhibiao。quezhenrengxuyikaojinyibudeyingxiangxuehexiangxideshenjinggongnengjiancha。
明德生物中枢神经特异性蛋白S100-β蛋白(S100-β)检测试剂盒是应用免疫层析技术，通过免疫定量分析仪判读，建立的快速、特异、简便的定量检测试剂盒，主要用于脑损伤的辅助诊断、监测病情变化、评估预后。不适用中枢神经系统肿瘤的治疗监测。
