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中枢神经特异性蛋白S100β在精神病科的应用
发布时间: 2018-08-14   点击:

  yi、zhongshushenjingteyixingdanbais100βdetexing

  s100βdanbaishis100jiazuzhongzhuyaode、zuijuhuoxingdechengyuan。gaileidanbaishuyusuanxinggaijiehedanbai,youmooredengshoucicongniunaozhongfenlihuode。yinqizaizhongxingphtiaojianxianengrongyu100%baoheliusuananrongye,gumingmingweis100danbai(moore, 1965)。

  s100βdanbaiyou2geβyajizucheng。2geβyajitongguobanguangansuancanjixingchengerliujian,yierjutihuoxingxingshicunzaiyushenjingyuanzhong。s100βdanbaitongguopangfenmihezifenmidaodabaowaizuoyongyushenjingyuanheshenjingjiaozhixibao,canyuca2+xinhaozhuandao,qishengwubanshuaiqiwei2 h,zaitineidaixiehoujingshenzangpaichu(wanglizhenheguguixiong,2008)。

cba下注平台  s100βdanbaizaipeitaiqidi14 djiuyouweiruobiaoda,suihouyushenjingxitongshengzhangfayuchengpingxingzengjiadeguanxi,chengnianhouxiangduiwending。zhengchangchengrenxueqingzhonghanliangxiaoyu0.18 ng/ml。shenglinongdudes100βdanbaishiyizhongshenjingyingyangyinzi,juyoucuyousifenliezuoyong,kediaojieshenjingjiaozhixibaodeshengzhang、zengzhi、fenhua,weichigaiwentai,cujinnaodefayu,bingzaixuexijiyizhongfahuiyidingzuoyong。dangshenjingjiaozhixibaobiaodas100βdanbaiguoliangshi,zehuichanshengshenjingduxing,jiasushenjingxitongyanzhengdeehua,bingdaozhishenjingxitonggongnengwenluan(wanglizhenheguguixiong,2008)。

  

cba下注平台  tu1 xingxingjiaozhixibaoyushenjing、naobuxueguandeguanxi。capillary,maoxixueguan;astrocyte,xingxingjiaozhixibao;axon,zhoutu;myelin,suiqiao;oligodendrocyt,shaotujiaozhixibao;myelinated axon,yousuiqiaodezhoutu。

  yue96%des100βdanbaicunzaiyunaonei,zhuyaodingweiyuzhongshushenjingxitongdexingxingxibao、shaotushenjingjiaozhixibaojizhouweishenjingxitongdexuewangxibao,shishenjingxitongdeteyixingdanbai。dangnaobuchuxiansunshangshi,ruquexuequeyanghuowaishangdaozhifuhans100βdanbaidexingxingjiaozhixibaohuaisi、diaowanghuozhefenmizengjia,daliangs100βdanbaishifangjinrunaobucbaxiazhupingtaiyezhong: yibufentongguopohuaidehuotongtouxingzengjiadexue-naopingzhangjinruxueyexunhuan,lingyibufenzetongguonao-naojiyepingzhangjinrunaojiyesuihoujingzhuwangmodoujinruxueyexunhuan,haiyouyibufenjingnao-naojiyepingzhang、xue-naojiyepingzhangjinruxueyexunhuan。xueyezhongdes100βdanbaishuipingzainaosunshanghouyouyidingdeshijianbianhuaguilv,erqieyunaosunshangchengdujiyuhoujinmixiangguan,wendingxingyoubiqitashenjingshenghuazhibiaogao,yincikeyizuoweinaosunshangdeteyixingbiaozhiwu。

cba下注平台  er、zhongshushenjingteyixingdanbais100βdelinchuangyingyong

  2.1 s100βzaijingshenfenlie、qingganzhangaidengjingshenjibingzhongdeyingyong

  s100βkeyizaijixingjingshenbingfabingshibeijiancechu,shidaibiaoshenjingxibaowanzhengxingdeshenghuabiaoji,yiners100βyuelaiyuebeizhongshi。

  2.1.1 jingshenfenliezheng

  jingshenfenliezhengshiyijibengexinggaibian,siwei、qinggan、xingweidefenlie,jingshenhuodongyuhuanjingdebuxiediaoweizhuyaotezhengdeyileizuichangjiandejingshenbing。

  rothermundtdeng(2001b)dui26lichuyujingshenfenliezhengjixingqideweiyongyaodebingrenjinxingyanjiu,jieguofaxianzaiweiqi6zhoudezhiliaoqianhuanzhexuejiangzhongs100βdeshuipingxianzhugaoyuzhengchangduizhaozu,zhiliaohouhuanzhexuejiangzhongs100βdeshuipingjiejinzhengchangduizhaozu。zaiduipianzhixingjingshenfenliezhenghuanzheyanjiuzhongfaxian,huanzhexuejiangzhongs100βyegaoyuzhengchangduizhaozu(steiner et al, 2006;lara et al, 2001)。

  lingwai,rothermundtdeng(2001b)zaiyanjiuzhonghaifaxianjingguo6zhouzhiliaohoujixingjingshenfenliezhenghuanzhedes100βdanbainongduyupanssyinxingyinzifenchengxianzhuzhengxiangguan。erguoneiyanjiuzhe(jijiawudeng,2001)zaiyanjiuzhongyefaxianshoufahuanzhejingguo12zhouzhiliaohouyijimanxingjibinghuanzhedes100βdanbainongduyupanssyinxingyinzifenchengxianzhuzhengxiangguan。zheibiaomings100βdanbainongduyujingshenfenliezhengyinxingzhengzhuangguanxigengweimiqie。

cba下注平台  2.1.2 qingganxingjingshenzhangai

  qingganxingjingshenzhangaishiyimingxianerchijiudexinjinggaozhanghuodiluoweizhudeyizujingshenzhangai,bingyouxiangyingdesiweihexingweigaibian,baokuozaokuangzheng、yiyuzheng(handancifazuohefanfufazuo)、shuangxiangqingganzhangai(hanzaokuangxiang、yiyuxianghehunhexiang)jiqitaqingganzhangai,kebanyoujingshenbingxingzhengzhuang,ruhuanjue、wangxiang。daduoshuhuanzheyoufanfufazuodeqingxiang,meicifazuoduokehuanjie,bufenkeyoucanliuzhengzhuanghuozhuanweimanxing。

  schreoeterdeng(2002)yongmianyifaguangfajiance20liqingganzhangaizhehuanzheji12lijiankangrenxues100βshuipingshifaxian,yiyuzhenghuanzhes100βdanbaishuipingzhongweishuyuzhengchangduizhaozubijiao,chayijuyoutongjixueyiyi。yongkangyiyuyaowuzhiliaohou,s100βdanbaijiangdichengduyuyiyuzhengyanzhongchengduyouguan。yincis100βdanbaibianhuakenengyuxingxingjiaozhixibaogaibianyouguan,tongguokangyiyuzhiliaoyoukenengshiqihuifu。rothermundtdeng(2001a)cedingle28lihuanyouyiyuzhengdehuanzhexuejiangzhongs100βdeshuiping,jieguoxianshiqis100βshuipingxianzhugaoyuzhengchangduizhaozu。yincis100βdanbaizaitishiqingganzhangaihuanzhedenaosunshangfangmianjuyoujiazhi。

  congjingshenfenliezhenghuoyiyuzhengdes100βjiancezhifanwei(xueqingyue0.120 ng/ml,naojiyeyue0.700 ng/ml)laikan,bingweiyoudaliangdeshenjingjiaozhihuoshenjingyuanshoudaopohuai,dankeyirenweijingshenfenliezhengdebingchengzhongcunzaizhejinxingxingdeshenjingbianxing。s100βzengjiakeyifanyingchutuibianjizhi,danzhengmings100βnongdudebianhuabanfanaobingligaibian,xuyaozaijiances100βdexueqinghenaojiyezhongnongdudejichushangjieheyingxiangjishuyijishenjingxinlixueceshidengfangmiandeyanjiu。

cba下注平台  2.2 zhongshushenjingteyixingdanbais100βzaidianxianxingchengzhongdeyingyong

cba下注平台  dianxianshimanxingfanfufazuoxingdeduanzannaogongnengshidiaozonghezheng,yinaoshenjingyuanyichangfangdianyinqifanfuxianxingfazuoweitezheng。dianxianshishenjingxitongchangjianjibingzhiyi,huanbinglvjinciyunaozuzhong。

cba下注平台  sendrowskideng(2004)fenbiecedinghuanyounaojishuihedianxianhuanerxuejiangzhongs100βdeshuipingfaxianliangzhedoucunzainongduzenggaodeqingkuang。ershiyongbiantaotijifamoxing,tongguobijiaos100βjiyinqiaochushuheyeshengxingshudechabie,diaochazaidianxianxingchengguochengzhongdezuoyong。jifahougenjuhaimatihebiantaotijiaozhixibaozhongsuanxingdanbaidebiaodapupingguxingxingjiaozhixibaodehuoxing,jieguoxianshiyeshengxinghejiyinqiaochushuxiangsi,erqieyeshengxingheqiaochushubingmeiyouxianzhubutongdehoufangdianyu。raner,qiaochushunengjifagengxunsu、zhengzhuanggengyanzhongdedianxian。zheixiejieguobiaomingzhengchangshuipingdes100βyouduikangdianxianxingchengdezuoyong(dyck et al, 2002)。yinci,tuiduans100βdanbaiquefadaozhixingxingjiaozhixibaozhongca2+chulinenglijiangdi,kenengshidianxianchanshengdeyuanyin。

cba下注平台  2.3 zhongshushenjingteyixingdanbais100βzaishenjingtuixingxingjibingzhongdeyingyong

  shenjingtuixingxingjibingshiyoushenjingyuanhuoqisuiqiaodesangshisuozhi。danaohejisuiyoushenjingyuanzucheng,shenjingyuanyoubutongdegongneng,rukongzhiyundong,chuliganjuexinxi,bingzuochujuece。danaohejisuidexibaoyibanshibuhuizaishengde,suoyiguodudesunhaikenengshihuimiexingde,bukenizhuande,bingsuizheshijiandetuiyierehua,yidaozhigongnengzhangai。

cba下注平台  2.3.1 aercihaimobing(ad)

cba下注平台  aerzihaimobingshiyizhongchixuxinggaojishenjinggongnenghuodongzhangai,jiandanjieshijiushizaimeiyouyishizhangaidezhuangtaixia,jiyi、siwei、fenxipanduan、shikongjianbianren、qingxudengfangmianfashenglezhangai。

  duiadhuanzhedeshijianyanjiuxianshi,adhuanzhenaocbaxiazhupingtaizhongsuohandes100β mrnahedanbaizhishuipingjunshenggao,bingfaxianadhuanzhewaizhouxuezhongmianyixibaodes100βbiaodazenggao。zaichengnianrennaonei,s100βzaishenjingkesuxingfangmianqizhongyaozuoyong,ers100βguodubiaoda,kedaozhixibaogujiashiwen、zengsheng,shutuhezhoututuibian,tuchushumujianshao,banyouxingweiyichang,biaoxianchuchidaidegezhongzhengzhuang。yanjiubiaomingadhuanzheyekeyounaogengsibingzao、baizhishusonghexueguanxingweixianyinsu。naoxueliudegaibiankeyinqidianfenyangdanbaideguodubiaoda,cijixingxingjiaozhihuohuahezengzhi,gutuices100βkenengzaiaddefasheng、fazhanjizhizhongyebanyanlezhongyaojiaose(guoyongmeideng,2005)。lingwai,xiaojiaozhixibaoguodubiaodail-1、xingxingjiaozhixibaoguodubiaodas100βyijit2+shenjingyuanxianweichanjiejieduandejinyibulianxiyibeizhengshi(donato et al, 2009)。xiangduijiankangduizhaohewanqiadhuanzhe,zaoqidaozhongqiadhuanzhes100βnaojiyenongdushenggao。wanqihuanzhehezhengchangrenwuchayishenzhigengdi。(lambert et al, 2007)。

  2.3.2 keyabing

cba下注平台  keyabingshiyizhonghanjiandezhuyaofashengzai50-70suidekechuanbodenaobing。shouganranderenkeyiyoushuimianwenluan、gexinggaibian、gongjishidiao、shiyuzheng、shijuesangshi、jirouweisuo、jizhenluan、jinxingxingchidaidengzhengzhuang,bingqieduohuizaifabingdeyinianneisiwang。

  keyabingshizhongshushenjingbianxingjibingzhongjinzhanzuikuaideyizhong,qijiaozhixibaozengshengyeshizuimingxiande。s100βdanbaizhuyaoyoujiaozhixibaofenmi,keyabinghuanzhenaojiyezhongs100βdanbaihanliangshenggao(kovacs et al, 2004),mingxiangaoyufeichidaizuheqitachidaizuhuanzhe(linshihedeng,2007)。

  2.3.3 jiweisuoxingcesuoyinghuazheng

  jiweisuoxingcesuoyinghuazhengshiyizhongyundongshenjingyuanjibing,duoyu30-50suifabing,yishangzhizhouweixingtanhuan,xiazhizhongshuxingtanhuan,shangxiayundongshenjingyuanhunhexing、duichengxingsunhaiweitedian,biaoxianweishouleibuweijirouweisuo。

  mighelideng(1999)baodaolejiweisuoxingcesuoyinghuazhenghuanzhedejisuishenjingjiaozhixibaoheyundongshenjingyuanzhongdes100βdanbaibiaodashangdiao。danshinaojiyezhongs100βnongduhuisuibingchengzengjiaerjiangdi,jifabingyuechidehuanzhedes100βdanbaishuipingyuedi(sussmuth et al, 2003)。

  san、zhongshushenjingteyixingdanbais100βzaijingshenbingkedeyingyong

  jingshenleijibinghuanzhedezhongshushenjingxitongdaixiewangwangcunzaizhangai,bufenshenjingxitongkenengcunzaisunshang。duiyujixingjingshenbingren,ketongguojiances100βdanbaidenongdu,dazhipanduanzhongshushenjingxitongsunshangdechengdu。danshi,gaizhibiaojinjinzuoweifuzhuzhenduanzhibiao。quezhenrengxuyikaojinyibudeyingxiangxuehexiangxideshenjinggongnengjiancha。

  明德生物中枢神经特异性蛋白S100-β蛋白(S100-β)检测试剂盒是应用免疫层析技术,通过免疫定量分析仪判读,建立的快速、特异、简便的定量检测试剂盒,主要用于脑损伤的辅助诊断、监测病情变化、评估预后。不适用中枢神经系统肿瘤的治疗监测。

  

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